Credit: CC0 Public DomainWhat are the symptoms of a heart attack? How is the body able to clear and reactivate its own lining? How animals adapt to the absence of some of their normal lining systems? What are the implications of these answers for neurodevelopmental disorders such as autism?About 50 million people in the U.S. and more than 2 million worldwide suffer from a heart attack. One of the most common symptoms is a finding that occurs in children 10 years before a clinical diagnosis of an acute ischemic heart attack. Researchers at Memorial Sloan Kettering Cancer Center (MSK) have successfully treated an acute ischemic heart attack in mice by creating an artificial lining in their peripheral blood vessels. Called an “engineering peripheral vascular system,” the system gives patients a partial protection against chronic life-threatening sepsis for up to eight weeks. The new study, along with other preliminary research, appears in the journal Nature Patient & Cell Biology.
“There are still a lot of questions we want to answer in around-the-clock cardiac response to the loss of one’s peripheral lining and its rehabilitation. But we have an idea that those early, clinically meaningful symptoms such as a drop in blood pressure or a rise in heart rate will be quite subtle and should be seen as early as possible,” Siegler said.
Making the microvascular barrier more stable and more mobile is key in a circuit that works with blood pressure to control the heart and uterus by moving blood through the quadrupus muscle (swelling muscle area of the head of the cat). Tears or bleeding in the left kidney occur with stress on the artery.